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Buprenorphine Practice Guidelines

The U.S. Department of Health and Human Services has published new practice guidelines regarding buprenorphine prescribing for opioid use disorder effective April 28, 2021. The new practice guidelines state:

The U.S. Department of Health and Human Services works to expand access to treatment for opioid use disorder by eliminating the x-waiver. There have since been updates to buprenorphine practice guidelines.
  • Eligible providers can now treat up to 30 patients without completing the previously required training

  • Qualified providers include physicians, physician assistants, nurse practitioners, clinical nurse specialists, certified registered nurse anesthetists, and certified nurse midwives with a valid medical license and valid Drug Enforcement Administration (DEA) registration

  • Eligible providers must still submit a Notice of Intent (NOI) to prescribe buprenorphine and will still receive an “X” DEA number

  • To treat more than 30 patients, providers must undergo required training. This can be completed online. Click here for more information

For more information, please visit SAMHSA’s FAQ page.

Buprenorphine practice guidelines have changed as of January 2023. Explore the resources below for more up-to-date prescribing guidelines.